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If however good conferred through the transformation in chromosome version numbers are designed for alleviating the workout tradeoffs exerted by aneuploidy, disease development may then end up being offered. Recently available findings connect chromosome missegregation making use of the demographic of DNA scratches (Fig.1) . Janssen et al. not too long ago indicated that falling back chromosomes captured within the spindle midzone are inclined to scratches because of the cleavage furrow during cytokinesis, linking chromosome missegregation to DNA harm, chromosome breaks and translocations . But some other research reports have perhaps not found considerable signs of DNA damage in merotelically linked lagging chromosomes . Instead, Crasta ainsi, al. reported that missegregated chromosomes which come to be exemplified in micronuclei include prone to DNA destruction and extensive DNA pulverization as a result problems in DNA duplication .

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